The United States has a long history of reliance on science to inform policy decisions. Today, science is employed on a daily basis to protect Americans’ health and safety, to bolster technological advancement, and to help the nation predict and prepare for security threats. It informs, illuminates, and steers our nation’s direction on everything from global security policy down to keeping safe the food and products in your home. As the ability of science to impact policy increases, however, the temptation also increases for political, ideological, and financial interests to manipulate or suppress inconvenient data. When science is undermined in such a manner, the public is left with laws and regulations that inadequately meet the needs of citizens. Today, the use of science in government is under threat from multiple fronts. Political, ideological, and financial interests are working to undermine the ability of science to inform federal decision‐making, harming the public good. The initial months of the Trump Administration have already raised new concerns. Executive orders, cabinet appointments of individuals with little expertise and clear conflicts of interest, and a sympathetic Congress all create new threats to the government’s ability to make science‐informed policy decisions. In recent cases, politics have overridden what should have been science‐based decisions by federal agencies. This Article will survey the history of federal scientific integrity and discuss the current risks to the federal scientific enterprise in three main areas: (1) corporate capture of the federal government; (2) dismantling the process of science‐based rulemaking; and (3) intimidation and control of scientists.