Environmental devastation of man-made origin threaten some of the most sensitive regions of Colombia, where the biodiversity found there is among the most unique in the world. Deforestation due to the cultivation and processing of coca and opium, the collateral damage to the environment from drug interdiction and eradication programs, and the slash and burn agriculture practiced by farmers involved in drug production and displaced indigenous groups forced out of their homelands by drug traffickers have had a drastic impact on Colombia’s precious national resources. The spillover effect of drug trafficking has also impacted sensitive environments in neighboring states, as well. For too long, the illegal armed groups and narcotraffickers causing the environmental devastation have gone without being held accountable for their damaging practices, and the inability of the Colombian government to confront drug-related environmental damage has resulted in increased stress on Colombia biodiversity and indigenous territories. This article examines the impact of drug cultivation and processing on the Colombian environment, the laws and enforcement capacity of the nation to fight it, and looks at how the nation and the international community can curtail the loss of more of Colombia’s natural treasures.